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    Associations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Province of Turkey
    (Springer, 2023) Arikan, Sanem; Oztuerk, Onur; Duygulu, Seniz; Atalay, Erol Omer; Atalay, Ayfer
    Although the etiopathogenesis of Behcet's disease is not known, studies conducted in different populations show that it is a multifactorial disease that is thought to develop as a result of the interaction of environmental and genetic factors. IL-17 is thought to induce the neutrophilic inflammation and the tissue damage mediated by immune response in patients. Polymorphisms in the gene region encoding IL-17 and IL-17R molecules may play a critical role in the pathogenesis of the disease and contribute to the elucidation of disease mechanism. We aimed to show the association of IL-17A, IL-17F, and IL-17RC polymorphisms and haplotypes in Behcet's disease patients and its clinical features. We genotyped IL-17A (rs4711998 (A/G), rs8193036 (C/T), rs2275913 (A/G), rs3819025 (A/G), rs8193038 (A/G), rs3804513 (A/T), rs1974226 (C/T), rs3748067 (C/T)); IL-17F (rs763780 (T/C), rs2397084 (T/C)); and IL-17R (IL-17RC) (rs708567 (C/T)) polymorphisms in 88 patients with Behcet's disease and 133 healthy controls using PCR-RFLP-based approach. The results of our study showed that polymorphisms of IL-17A, rs8193036 (C/T), rs3819025 (G/A), rs3804513 (A/T), IL-17F rs2397084 (T/C), and IL-17RC rs708567 (C/T) are associated with the susceptibility to the BD. When the haplotype distributions of all loci of IL-17Aand IL-17A/IL-17F together were examined and in contrast to the data obtained from the controls, the GTGGAACC (27.84%) and GTGGAACCTT (25.57%) have the highest frequencies. In conclusion, the allele and genotype frequency differences of the IL-17A, IL-17F, and IL-17R and haplotype frequencies between Behcet's disease and controls indicate that the genetic structure of Behcet's disease may be different.
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    Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population
    (Mdpi, 2026) Arikan, Sanem; Ozturk, Onur; Atalay, Ayfer; Atalay, Erol Omer
    Beh & ccedil;et's disease is a chronic, multisystem inflammatory disorder characterized by recurrent mucocutaneous and ocular manifestations, in which genetic factors, particularly cytokine gene polymorphisms, are thought to contribute to disease susceptibility. This study aimed to investigate the association of Interleukin-12B and Interleukin-23R gene polymorphisms and haplotype distributions with Beh & ccedil;et's disease in Denizli, a province of Turkey. A total of 88 patients with Beh & ccedil;et's disease and 133 healthy controls were genotyped for Interleukin-12B (rs3213119, rs3213120, rs3212227, rs3213113, rs2082412) and Interleukin-23R (rs1004819, rs7517847, rs7530511, rs10489629, rs10889677) polymorphisms using polymerase chain reaction-restriction fragment length polymorphism analysis. Genotype, allele, and haplotype distributions were evaluated for associations with Beh & ccedil;et's disease risk and clinical manifestations. The results demonstrated that the Interleukin-12B rs2082412 G allele and rs3213119 G allele were associated with increased risk of Beh & ccedil;et's disease. Additionally, the Interleukin-23R rs7530511 TT genotype and rs10489629 GG genotype and G allele were significantly associated with Beh & ccedil;et's disease susceptibility. Haplotype analyses revealed AAAGG and GTCAC as the most frequent haplotypes in Interleukin-12B and Interleukin-23R loci, respectively, in both patients and controls. These findings suggest that Interleukin-12B and Interleukin-23R gene polymorphisms and haplotypes may be associated with Beh & ccedil;et's disease susceptibility and clinical heterogeneity in this population.