Yazar "Akkoç, Mitat" seçeneğine göre listele

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    Ftalimit Sübstitüe Ag(I) NHC Komplekslerinin Sentez ve Karakterizasyonu
    (2022) Akkoç, Mitat
    N-Heterosiklik karbenler (NHC’ler) organometalik kimyanın en önemli ligantlarındandır. 1991 yılında Arduengo ve arkadaşlarının ilk kararlı karbeni izole etmesi ile organometalik kimyaya önemli bir ligant kazandırmış oldu. Karbenlerin hem sterik hem de elektronik kararlılığı sayesinde organometalik kimyada kullanılan diğer ligantlardan daha fazla dikkat çekmesine neden oldu. NHC’lerin 1 ve 3 konumundaki sübstütientlerin değiştirilebilmesi de yapının tasarlanmasında önemli avantajlar sağlamaktadır. Karbenler peryodik tablodaki iç geçiş elementlerinin çoğu ile kompleks oluşturabilmektedir. Bu oluşturduğu kompleksler katalizör, ilaç, iyonik sıvı, MOF, iletken material ve lüminesans madde gibi birçok alanda uygulama alanı bulduğunu görmekteyiz. Cis-platin bir antikanser ajanı olarak kullanılmasından sonra metal tabanlı bileşiklerin bu alanda araştırılmasının önü açılmış oldu. Son yirmi yılı incelediğimizde Ag-NHC bileşiklerinin antikansorojen ve antimikrobiyal ajan olarak yoğun bir şekilde çalışmaların sürdürüldüğünü görmekteyiz. Gümüş karben bağının kuvvetinden dolayı oluşan yapısal kararlılık hücre içerisinde daha geç bozunmasına sebep olmaktadır. Böylelikle; hem daha az miktarda kullanılmakta hem de daha uzun süre etkisini yitirmeden ortamda var olabilmektedir. Bu çalışmamızda biyolojik olarak aktif bir yapı olan ftalimit gruplarını içeren bir seri gümüş komplekslerinin sentez ve karakterizasyon çalışmaları başarı ile gerçekleştirilmiştir.
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    Highly Active Fe3O4@SBA-15@NHC-Pd Catalyst for Suzuki–Miyaura Cross-Coupling Reaction
    (Springer, 2021) Akkoç, Mitat; Buğday, Nesrin; Altın, Serdar; Özdemir, İsmail; Yaşar, Sedat
    A novel Pd-NHC functionalized magnetic Fe3O4@SBA-15@NHC-Pd was synthesized and used as an efficient heterogeneous catalyst in the Suzuki–Miyaura C–C bond formation reactions. The Fe3O4@SBA-15@NHC-Pd characterized by X-Ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray analysis (EDX), Thermogravimetric Analysis (TGA), Differential Thermal Analysis (DTA). The Inductively Coupled Plasma-Optical emission spectroscopy (ICP-OES) analysis was used to determine the exact amount of Pd (0.33 wt%) in Fe3O4@SBA-15@NHC-Pd. The TEM images of the catalyst showed the existence of palladium nanoparticles immobilized in the catalyst's structure, while no reducing agent was used. The NHC moieties in the catalyst structure could be stabilize Pd(0) nanoparticles prevents agglomeration. The magnetic catalyst was effectively used in the Suzuki–Miyaura cross-coupling reaction of substituted phenylboronic acid derivatives with (hetero)aryl bromides in the presence of a K2CO3 at room temperature in aqueous media and magnetic catalyst could be simply extracted from the reaction mixture by an external magnet. Different aryl bromides were converted to coupled-products in excellent yields with spectacular TOFs values (up to 1,960,339 h?1); in the presence of 1 mg of Fe3O4@SBA-15@NHC-Pd catalyst (contains 3.1?×?10–6 mol% Pd) at room temperature in aqueous media. After reusability experiments, it is found that this catalyst was effectively used up to ten times in the reaction with almost consistent catalytic efficiency. A decrease in the activity of the 10th reused catalyst was found as 9%.
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    N-heterocyclic carbene Pd(II) complex supported on Fe3O4@SiO2: Highly active, reusable and magnetically separable catalyst for Suzuki-Miyaura cross-coupling reactions in aqueous media
    (Elsevier, 2021) Akkoç, Mitat; Buǧday, Nesrin; Altın, Serdar; Kiraz, Nadir; Yaşar, Sedat; Özdemir, İsmail
    A new type magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs heterogeneous catalyst was fabricated and characterized by Fourier Transform Infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Energy Disperse X-ray analysis (EDX), Thermogravimetric Analysis (TGA), Differential Thermal Analysis (DTA), and Scanning Electron Microscopy (SEM). The loading amount of Palladium (Pd) to magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs was measured by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) analysis. The catalytic activity of magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs heterogeneous catalyst was examined on Suzuki-Miyaura cross-coupling reactions of aryl halides with different substituted arylboronic acid derivatives. All coupling reactions yielded excellent results and high TOF (up to 76528 h?1) in the presence of 2 mg of Fe3O4@SiO2@NHC@Pd-MNPs catalyst (0.0197 mmolg?1, 0.00394 mmol%Pd) at 80 °C in 2-propanol/H2O (1:2). In addition, the magnetic nano Fe3O4@SiO2@NHC@Pd-MNPs catalyst was easily recovered by using an external Nd-magnet and reused for the Suzuki cross-coupling reactions. The catalyst showed strong structural and chemical stability and was reused six times without losing its catalytic activity substantially.
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    Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells
    (2022) PAŞAHAN, RAMAZAN; Akkoç, Mitat; YAŞAR, Şeyma; Köprülü, Tuğba Kul; tekin, saban; yaşar, sedat; Özdemir, İsmail
    The 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). The Ru(II)-NHC complexes (4a-h) were synthesized via transmetalation reaction from 3a-e. 4a-h complexes were converted to Ru(II)-NHC.HCl complexes (5a- h) by HCl solution of diethyl ether and characterized by different spectroscopic techniques such as $^1H and ^{13}C$ NMR, LC/MS-Q-TOF, FT-IR, elemental analysis, and melting point detection. We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay. The $IC_{50}$ value of 5b, 5c and 5e complexes exhibited good cytotoxic activity than cisplatin on C6 (14.2 ± 0.5 mM; 16.2 ± 0.4 mM; 24.2 ± 0.7 mM, respectively) and HeLa (11.1 ± 0.5 mM; 13.7 ± 0.3 mM; 22.8 ± 0.8 mM, respectively) cell lines.