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    İnme Merkezinde Takip Edilen Hastaların Klinik Özelliklerinin ve Tedavi Verilerinin Retrospektif Kohort Çalışması ile Değerlendirilmesi : İki Yıllık Analiz
    (Tokat Gaziosmanpaşa Üniversitesi, 2024) Akalin, Yahya; Çakmak, Erkan; Gözel, Nevzat; Taşcı, İrem
    Amaç: Hastanemiz inme merkezinde iskemik inme tanısıyla yatıp tedavisi yapılan hastaların klinik özellikleri ve tedavi açısından incelenmeleri amaçlandı. Gereç ve Yöntem: Bu çalışma 1 Mart 2019 -1 Mart 2021 tarihleri arasında inme merkezimizde yatarak tedavi edilen hastaların standart veri formları ile kayıt altına alınmış olan bilgileri retrospektif olarak analiz edilerek yapılmıştır. Bulgular: Çalışmada yer alan 125 hastanın %56,8’ i kadın, %43.2’ si erkek idi. Hastalarda en sık tespit edilen risk faktörü hipertansiyondu. Hastaların %76’ sı tromboemboli profilaksisine yönelik en az bir ilaç kullanmaktaydı. Hastaların %72,8’ de anterior dolaşım alanı, %27,2’ de ise posterior dolaşım alanı etkilenmişti. Hastaların %84,8’ inde semptom-kapı zamanı 180 dk ve daha kısa idi, kapı-iğne zamanı ortalama 52 dk olarak hesaplandı. 71 hastaya sadece i.v. tPA tedavisi, 42 hastaya hem i.v. tPA hem de mekanik trombektomi uygulanmış, 12 hastaya ise sadece mekanik trombektomi uygulaması yapılmıştı. Hastaların yoğun bakımda kalış süreleri ortalama 9 gün olup kadınlarda ortalama 8,6 gün, erkeklerde ise 9,4 gün olarak tespit edildi. 39 hastada mekanik ventilasyon ihtiyacı gelişti. 16’sı kadın, 10’ u erkek hasta olmak üzere toplam 26 hastada ölüm gerçekleşti. Sonuç: İskemik inme insidansı yıllar içerisinde sürekli artmaktadır. Bu hastalarda trombolitik tedavi başlanmasında gecikmeler olmaması için ülkemizde inme merkezi sayılarının hızla arttırılması gerekmektedir.
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    Otolin-1 as a biomarker for the evaluation of the effectiveness of betahistine treatment for benign paroxysmal positional vertigo
    (Wolters Kluwer Medknow Publications, 2023) Karaer, Isil Cakmak; Urhan, Ayca; Akalin, Yahya
    ObjectiveBenign paroxysmal positional vertigo (BPPV) is the most common vertigo disorder. Betahistine is the most commonly used drug in the treatment of vertigo, however its effect on the inner ear is not fully known. Otolin-1 is an inner ear-specific glycoprotein that can be identified in peripheral blood. The aim of the study was to determine the effect of treatment of betahistine for BPPV on serum otolin-1 levels.MethodsThirty (30) patients with BPPV and 30 healthy controls were enrolled in the study. Serum otolin-1 levels were measured before and 14 days after perioral (po) betahistine treatment in the BPPV group, whereas otolin-1 level was examined once in controls. The efficacy of treatment was evaluated with Dizziness Handicap Index (DHI) and Visual Analog Scale (VAS) in the BPPV group.ResultsOtolin-1 levels were statistically significantly higher in patients with BPPV than controls. In the BPPV group, serum otolin-1 level was found to be statistically significantly lower after betahistine treatment. There was a statistically significantly difference between pre-treatment and posttreatment groups regarding to both DHI and VAS scores.ConclusionSerum otolin-1 can be used as a biomarker in monitoring the effectiveness of treatment of BPPV with betahistine as well as diagnosis of BPPV.
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    The Effect of Warm Foot Baths on Sleep Quality, Fatigue, and Bowel Function in Patients With Stroke
    (Lippincott Williams & Wilkins, 2026) Cevik, Seher; Ozden, Gurkan; Ceviz, Ahmet; Saritas, Seyhan Citlik; Akalin, Yahya
    BACKGROUND:Ischemic stroke patients commonly experience sleep disturbances, fatigue, and bowel dysfunction, which negatively impact rehabilitation outcomes. Non-pharmacological interventions such as warm foot baths may offer supportive benefits. This study aimed to examine the effects of warm foot baths on sleep quality, fatigue, and constipation severity in patients with stroke. METHODS:A pretest-post-test control group design was used. The study was conducted between September 2024 and June 2025 with patients hospitalized for stroke at the neurology clinic of a training and research hospital in Eastern Turkey. The study population consisted of patients diagnosed with stroke who were followed up at the aforementioned unit during the study period. The 96 participants included 51 in the experimental and 45 in the control group; based on an effect size of 0.60, alpha=0.05, and power=0.95. Data were collected using the Personal Identification Form, Fatigue Severity Scale, Constipation Severity Scale, and Richards-Campbell Sleep Questionnaire. The experimental group received a 20-minute warm foot bath 30 minutes before bedtime for 1 week, whereas the control group received routine care only. RESULTS:Foot baths did not significantly reduce fatigue compared with the control group. However, significant improvements were observed in constipation severity and sleep quality in the experimental group (P<0.001). CONCLUSION:Warm foot baths were effective in reducing constipation severity and improving sleep quality in patients with stroke. The results suggest that foot baths can be considered a supportive and feasible complementary care approach for managing symptoms in patients with stroke. These findings support the use of non-pharmacological interventions in stroke rehabilitation.