Yazar "Akbulut, Ekrem" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
Akbulut, Ekrem; Yıldırım, Tülay; Öztürk, Onur (2022)Objectives: Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated ... -
Investigation of changes in protein stability and substrate affinity of 3CL-protease of SARS-CoV-2 caused by mutations
Akbulut, Ekrem (Sociedade Brasileira de Genetica, 2022)3CLpro of SARS-CoV-2 is one of the enzymes required for the replication process of the virus responsible for the COVID-19 pandemic. In this study, changes in protein stability and substrate affinity caused by mutations ... -
Mutations in the SARS CoV-2 spike protein may cause functional changes in the protein quaternary structure
Akbulut, Ekrem (Turkish Journal of Biochemistry, 2021)Objectives: This study aimed to model the changes resulting from mutations in surface (spike/S) glycoproteins, which play a key role in the entry of the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) into ... -
The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis
Akbulut, Ekrem; Yolbas, S; Ozgen, M (WALTER DE GRUYTER GMBHGENTHINER STRASSE 13, D-10785 BERLIN, GERMANY, 2021)Objectives: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which ... -
SARS CoV-2 Spike glycoprotein mutations and changes in protein structure
Akbulut, Ekrem (Trakya Üniversitesi, 2021)Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2) is a single-stranded positive polarity RNA virus with a high virulence effect. Spike (S) glycoprotein is the outermost component of the SARS CoV-2 virion and ...