Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
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info:eu-repo/semantics/openAccessTarih
2022Yazar
Otlu, ÖnderErdem, Mehmet
Korkmaz, Kübranur
Günay, Özge Ota
İn, Erdal
Kıran, Tuğba Raika
Bay Karabulut, Aysun
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Erdem, Ö. O. M., Korkmaz, K., Günay, Ö. O., İn, E., Kıran, T. R., & Karabulut, A. B. (2022). Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study. Int J Acad Med Pharm, 4(1), 60-64.Özet
Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and
hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron),
inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation
(prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical
COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients
diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory
test results were elicited from electronic medical records and compared to 50 healthy people. A statistically
significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical
COVID-19 patients compared with healthy people while a statistically significant decrease was observed in
hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed.
Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors
might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in
COVID-19 in vivo and in vitro.