Investigation of the Effectiveness of Polyurethane Composites Containing Gelatin at Different Rates on the Release of Ciprofloxacin

Abstract

Recently, polyurethane materials are widely used for many application areas such as drug delivery systems, biomaterial production, etc. In this study, polyurethane structures containing different amounts of gelatin (5%, 10%) were prepared. A release system was designed with ciprofloxacin adsorption to the prepared polyurethane structures. The structural characterization, thermal properties, surface morphologies of the designed system were determined using appropriate techniques. Monitoring of ciprofloxacin release was carried out by UV-spectrophotometer. It was determined that polyurethane structures containing different proportions of gelatin supported the adsorption of ciprofloxacin and the release slowed down with the increasing gelatin ratio. With this study, many drug delivery systems that can release at different rates and durations depending on the amount of gelatin additive can be designed.