Prognostic value of glucose fluctuation in patients undergoing thrombolysis or thrombectomy due to acute ischemic stroke
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2021Yazar
Çıplak, Sibel
Üst veri
Tüm öğe kaydını gösterKünye
Çıplak, S., Adıgüzel, A., Öztürk, U., Akalın, Y. (2021). Prognostic value of glucose fluctuation in patients undergoing thrombolysis or thrombectomy due to acute ischemic stroke. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 57(1), 1-7.Özet
Background: Hyperglycemia during acute ischemic stroke is associated with worse outcomes, and this glucose
altitude may persist in the initial days. In this study, we investigate the efect of glucose fuctuations in the frst 4 days
in patients diagnosed with acute ischemic stroke and who underwent ivr-tPA±interventional thrombectomy or only
interventional thrombectomy on stroke prognosis. Study was designed bicentered retrospective case series. Patients
older than 18 years were included and those suitable for acute treatment, treatment indications, contraindications,
and treatment management of hyperglycemia were selected according to the 2018 American Stroke Association
guidelines. The efect of fasting glucose values of patients in the frst 4 days on admission and 24th hour NIHSS scores,
duration of hospitalization, disability, mortality, and prognosis were analyzed. We aimed to demostred the efect of
the frst 4-day glucose values measured in patients treated in a stroke center on clinical prospect.
Results: One hundred and seventy-six patients were included in the study. Group 1 included 30 (17%) patients with
severe clinical condition (NIHSS at admission≥16), and Group 2 comprised 146 (83%) patients with moderate and
mild clinical condition (NIHSS at admission<16). The glucose values of Groups 1 and 2 were found as follows: day
1 (admission): 178.7±10.3 mg/dl and 138.3±54.9 mg/dl, day 2: 197.7±99.8 mg/dl and 137.6±51.8 mg/dl, day 3:
186.1±97.6 mg/dl and 127.5±50.0 mg/dl, and day 4: 169.2±85.0 mg/dl and 126.7±49.3 mg/dl (p<0.05). Mortality
risk of patients with glucose≥200 mg/dl was 43.5% on day 1 (p>0.05), 57.1% on day 2, 68.4% on day 3, and 76.5% on
day 4 (p<0.05).
Conclusions: The glucose level of patients in severe clinical condition peaked on the second day and that 4 days of
resilient severe hyperglycemia is a negative risk factor for sequela and mortality.