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The Effects of SARS CoV-2 nsp13 Mutations on the Structure and Stability of Helicase in Chinese Isolates
(İstanbul Üniversitesi / İstanbul University, 2022)
Objective: Coronavirus Disease 2019 (COVID19) is a viral disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). The high mutation propensity of the SARS CoV-2 genome is one of the biggest threats ...
Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
(2022)
Objectives: Endoplasmic reticulum aminopeptidase-1
(ERAP1) polymorphic changes cause autoimmunity. To
understand the contribution of ERAP1 to the occurrence of
rheumatoid arthritis (RA) disease, we investigated ...
Investigation of changes in protein stability and substrate affinity of 3CL-protease of SARS-CoV-2 caused by mutations
(Sociedade Brasileira de Genetica, 2022)
3CLpro of SARS-CoV-2 is one of the enzymes required for the replication process of the virus responsible for the COVID-19 pandemic. In this study, changes in protein stability and substrate affinity caused by mutations ...